What Is Keytruda?
Discover how Keytruda is used to treat advanced skin cancer in the U.S. Learn about symptoms, diagnosis, and how this immunotherapy compares to other top treatments.
Keytruda (pembrolizumab) is an FDA-approved immunotherapy drug that helps the immune system detect and destroy cancer cells. It belongs to a class called PD-1 inhibitors and is commonly prescribed to treat several cancers, including:
Advanced melanoma (skin cancer)
Merkel cell carcinoma
Cutaneous squamous cell carcinoma (CSCC)
It is often used when skin cancer has spread or become unresectable (not removable by surgery).
Common Skin Cancer Symptoms to Watch For
Early detection is key, and symptoms can vary depending on the type of skin cancer. Here are common signs:
1. Melanoma Symptoms
A changing mole or skin lesion
Asymmetry, irregular borders, color variation
Diameter larger than a pencil eraser
Evolving appearance or bleeding
2. Squamous Cell Carcinoma (SCC)
Rough, scaly patches or open sores
Raised growths with a central depression
May crust or bleedeasily
3. Basal Cell Carcinoma (BCC)
Pearly or waxy bumps
Flat, flesh-colored or brown lesions
Sores that don’t heal
4. Merkel Cell Carcinoma
Fast-growing, painless nodules
Typically appears on sun-exposed skin
Often mistaken for cysts or benign bumps
If any skin change is persistent or suspicious, a dermatologist should evaluate it right away.
How Keytruda Works for Skin Cancer
Keytruda blocks PD-1, a protein that stops immune cells from attacking cancer. By inhibiting this checkpoint, Keytruda:
Restores T-cell activity
Enhances immune response against cancer cells
May shrink tumors or stop progression
It’s typically administered as an intravenous infusion every 3 to 6 weeks.
Key Benefits of Keytruda
Prolongs survival in advanced melanoma patients
May delay recurrence after surgery in resected melanoma
Treats skin cancers resistant to surgery or radiation
Generally fewer side effects than traditional chemotherapy
Potential Side Effects
While many patients tolerate Keytruda well, side effects can include:
Fatigue
Rash
Diarrhea
Cough or shortness of breath
Immune-related reactions (thyroid, liver, lung inflammation)
Always report symptoms early to your oncology team for monitoring and management.